Genetic variants in thyroid cancer distant metastases
نویسندگان
چکیده
منابع مشابه
Genetic variants in thyroid cancer distant metastases.
1 Steven E. Justiniano, Joseph P. McElroy, Lianbo Yu, Ayse Selen Yilmaz, Kevin R. 2 Coombes, Leigha Senter, Rebecca Nagy, Paul Wakely, Jr, Stefano Volinia, Michelle 3 Vinco, Thomas J. Giordano, Carlo M. Croce, Motoyasu Saji, Matthew D. Ringel 4 1 Division of Endocrinology, Diabetes, and Metabolism, Center for Biostatistics and Department 5 of Bioinformatics; Division of Human Genetics, 4 Depart...
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Distant metastases from thyroid cancer of follicular origin are uncommon. Treatment includes levothyroxine administration at suppressive doses, focal treatment modalities with surgery, external radiation therapy and thermal ablation, and radioiodine in patients with uptake of (131)I in their metastases. Two thirds of distant metastases will become refractory to radioiodine at some point, and wh...
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The remarkably good prognosis and long-term survival in differentiated thyroid cancer (DTC) are significantly reduced in patients with distant metastasis (DM). Multi-site metastases are associated with a high mortality rate reaching 92% at 5 years necessitating early diagnosis and treatment. The most common site of metastases are the lungs, followed by the bone, with the former having better pr...
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Medullary thyroid carcinoma (MTC) is an infrequent calcitonin-producing neuroendocrine tumor that initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, ...
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BACKGROUND Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP). METHODS We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid ca...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2016
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-16-0351